LSBS 5672-0

Brief

Ribonucleic acid (RNA) biology has become one of the most influential areas in modern biology and biomedicine. The discovery of numerous novel classes of RNAs has revolutionized molecular biology, with profound impact on clinical sciences. In this course, we will first describe the basic knowledge on RNA, followed by various experimental approaches used for characterization of RNAs and RNA-protein complexes. We further elaborate recent advent of a series of effective RNA-ba<x>sed therapeutics against diseases that cannot be treated with other conventional drug groups.

Description

Course keywords: RNA, RNA therapy, RNAi, mRNA, antisense oligonucleotide, aptamer 課程說明 In this course, we will first describe the basic knowledge on RNA, followed by various experimental approaches used for characterization of RNAs and RNA-protein complexes. We further elaborate recent advent of a series of effective RNA- based therapeutics against diseases that cannot be treated with other conventional drug groups. In the final part of this course, each student will give an oral presentation in the class and lead the group discussion. The topic will be announced later. 參考書籍 Fundamentals of RNA structure and function Grover, Neena, editor.; 2022 Springer Nature eBook Various scientific papers from journals (nature methods, etc.) RNA therapeutics : the evolving landscape of RNA therapeutics Giangrande, Paloma H., Franciscis, Vittorio de, Rossi, John J.; 2022 Academic Press, 教學進度 Week 1. Composition and architecture of RNA Week 2. Catalytic RNA: Ribozyme and spliceosome Week 3. RNA modifications Week 4. RNA-protein interaction Week 5. RNA Methodologies I Week 6. RNA Methodologies II Week 7. Oral presentation: Scientists behind the RNA revolution I Week 8. Oral presentation: Scientists behind the RNA revolution II Week 9. mRNA Therapeutics and Functional Implications Week 10. ASO Therapeutics and Functional Implications Week 11. siRNA Therapeutics and Functional Implications Week 12. miRNA Therapeutics and Functional Implications Week 13. Aptamer Therapeutics and Functional Implications Week 14. Drug delivery systems for RNA therapeutics Week 15. Oral presentation: Case study of RNA therapy I Week 16. Oral presentation: Case study of RNA therapy II 成績考核 100% Oral presentation and discussion

Timetable

Scores

Average Percentage 93.14

Std. Deviation 2.1

Remarks

16週

Restrictions

Compulsory

Elective

Cross Discipline

First Specialization

Second Specialization