LSBS 5648-0

Brief

使用生物物理學方法探討結構生物的課題，方法包括X光射線大分子晶體學，同步加幅射的應用，小角度X光射線散射，質譜， 核磁共振，電子自旋共振和計算生物學等。 To study structural biology topics using biophysics methods including X-ray Macromolecular Crystallography, Synchrotron Protein Crystallography, Small Angle X-ray Scattering, Mass spectrometry, NMR, Electron Spin Resonance and computational biology etc.

Description

Course keywords: 分子結構 , 生物功能, 蛋白質化學, 生物物理, 結構生物學的應用 Molecular structure, Biological function, Protein chemistry, Biophysics, Application of structural biology 一、課程說明(Course Description) The topics include: 1) Basic structure principles 2) Protein structure conformational change 3) Protein stability & folding 4) The structural biology study in solution by UV and CD spectroscopies 5) The structural biology analysis by X-ray, NMR and Mass. 6) Synchrotron radiation study in structural biology etc 二、指定用書(Text Books) 1) Alan Fersht "Structure and Mechanism in Protein Science, 1999" 2) Carl Branden & John Tooze "Introduction to Protein Structure" 1999 三、參考書籍(References) 1) Methods in Enzymology, volume 246, Chapters 1-4. (1995) Academic Press. 2) Introduction to Biophysical Methods for Protein and Nucleic Acid Research, J. A. Glasel and M. P. Deutscher, ed., Chapter 6 only. (1995) Academic Press 3) Introduction to Protein Structure Branden & Tooze (1999) 4) Protein struture and funciton gregory A Petsko & Dagmer Ringe (2004) 5) Teachers' in class handout 四、教學方式(Teaching Method) In-class lecture. 五、教學進度(Syllabus) According to syllabus 六、成績考核(Evaluation) Two in-class examines and each one is 50% of the final score. 七、可連結之網頁位址

Timetable

Scores

Average Percentage 85.75

Std. Deviation 4.58

Remarks

16週

Restrictions

Compulsory

Elective

Cross Discipline

First Specialization

Second Specialization