ESS 5845-0

Brief

本課程以一學期時間教授奈微米尺度之生物醫學及流體系統相關之工作原理、基本架構、以及其廣泛之應用。 課程首先以四週時間簡介奈微米技術及基礎生化及分生技術，之後在期中考前介紹基本之生醫檢測技術及奈微流體操控生醫分 子技術。期 中考之後則以不同專題探討奈微米生醫特殊之技術及其應用，與生醫分子動態模擬與實驗方法。期末以學生分組針對不同專題 進行報告方 式進行。 This course provides an in-detail instruction on the fundamental principles, basic fr<x>ame works, and the variety of applications to biomedical and fluidic systems in micro or nano scale. Before midterm examination, fundamental micro/nano fabrication methods, basic analytical Biochemistry principles, and general micro/nano fluidic physics and devices will be introduced. After the midterm 5 specific applications for micro/nano biomedical/fluidic systems will be elaborated. Students will then be arranged into several groups for preparing final projects and reports.

Description

Course keywords: Nano drug delivery, BioMEMS, MicroFluidics, Biosensors, Single molecule detection, Tissue engineering 一、課程說明(Course Description) 2023 Tentative Outline for Nano/Micro Biomedical and Fluidic Systems: Introduction to Micro/Nano biomedical and Fluidic Systems (2/16, Prof. FG Tseng) Micro/nano fabrication technology (2/23, Prof. FG Tseng, HW#1) Micro/nano biosensors I (3/2 Dr. Goudar) Micro/nano biosensors II (3/9 Dr. Goudar, HW#2) Fundamentals of analytical Biochemistry (3/16, Prof. CC Yang) Fundamentals of Molecule Biology (3/23, Prof. CC Yang) Micro/nano fluidic physics (3/30, Prof. FG Tseng) Micro/nano Fluidic Systems I, II (4/13,4/20 Prof. FG Tseng, HW#3) Midterm (4/27, Dr. Goudar) Nano-bio detection technology (5/4, CC Yang) Nano particle fabrication and medical applications (5/11, Prof. CC Yang) Molecular self assembly and surface modification (5/18, Dr. Goudar) Molecular dynamic simulation (5/25, Dr. Goudar) Single Molecule Detection Technologies (6/1, Prof. F-G Tseng) Final oral presentation (6/8, Prof. F-G Tseng, Dr. Goudar), Final report (6/8) 2/27-28 Peace Memorial day, 4/3-6 spring holiday 二、指定用書(Text Books) Textbooks: 1. 奈微米生醫及流體系統講義, 曾繁根、楊重熙,Lecture Handouts of Nano/Micro Biomedical and Fluidic systems, www.ess.nthu.edu.tw/~fangang 三、參考書籍(References) References: 1. Robert A. Freitas Jr.“Nanomedicine Volume I: Basic Capabilities”, Landes Bioscience, Austin, Texas, USA, 1999. 2. K. Eric Drexler, “Nanosystems”, John Wiley & Sons, Inc., New York, USA, 1992. 3. Gregory Timp edited, “Nanotechnology”, Springer-Verlag, New York, USA, 1999. 4. Brian Eggins, “Biosensors-an Introdcution”, Wiley & Ueubner, New York, 1996. 5. Alice J. Cunningham, “Introduction to Bioanalytical Sensors”, John Wiley & Sons, Inc, New York, 1998. 6. Boisde Harmer, “Chemical and Biochemical Sensing with Optical Fiber and Waveguides”, Artech House, Inc, USA, 996. 7. Greg T. Hermanson, “Bioconjugate Techniques”, Academic Press, 1996. 8. Micromachined Transducers source book, Gregory T.A. Kovacs, McGraw Hill, 1998 9. Fundamentals of Microfabrication, Marc Madou, CRC Press, 1997. 四、教學方式(Teaching Method) Lecture 80%, exam: 5%, student project and presentation 15% 五、教學進度(Syllabus) 1. Introduction to Micro/Nano biomedical and Fluidic Systems 奈微米生醫及流 體系統簡介(1週, 曾 繁根教授) 2. Micro/nano fabrication technology 生醫奈微米結構製程技術/奈微米流體物理 (1 週, 吳仁貴博士) 3. Micro/nano fluidic physics 生醫奈微米結構製程技術/奈微米流體物理 (1週, 吳仁 貴博士) 4. Micro/nano biosensors I奈微米生醫感測系統I (1週, 吳仁貴博士) 5. Micro/nano biosensors II 奈微米生醫感測系統II (1週, 吳仁貴博士 ) 6. Fundemental of analytical Biochemistry 生物化學基礎 (1週, 楊重熙教授 ) 7. Spring holiday on earlier April 8. Fundemental of Molecule Biology 分子生物學基礎 (1週, 楊重熙教授) 9. Micro/nano Fluidic Systems I 奈微米熱流系統I-連續流體系統 (1週, 曾繁根教授 ) 10. Micro/nano Fluidic Systems II 奈微米熱流系統II-數位流體系統 (1週, 曾繁根教 授 ) 11. Midterm 期中考 (一週, 吳仁貴博士 ) 12. Nanobio detection technology 奈米生醫檢測技術 (1週, 楊重熙教授) 13. Nano particle fabrication and medical applications 奈米顆粒之備製與醫學檢 測應用(1週, 楊重熙 教授 ) 14. Melecular self assembly and surface modification 奈米自我組裝分子與表面修 飾技術 (1週, 王本 誠教授) 15. Molecular dynamic simulation 生醫分子之奈米尺度計算模擬 (1週, 陳馨儀 教授) 16. Micro/nano array and single molecule detection 微陣列生物晶片/單分子操控及 檢測技術/奈微流 體檢測技術 (1週, 吳仁貴博士 ) 17. Final oral presentation/final report 期末口頭報告 (1週, 吳仁貴博士, 曾繁根 教授), 書面報告繳交:（口頭 報告下一週） 六、成績考核(Evaluation) Homework: 20%, Midterm: 30%, Presentation: 20%, final report: 30% 七、可連結之網頁位址 (web connection) http://fangang.web.nthu.edu.tw

Timetable

Scores

Average Percentage 81.4

Std. Deviation 20.75

Remarks

Restrictions

Compulsory

Elective

Cross Discipline

First Specialization

Second Specialization