Holiday
LS II生二206 M3M4
Liquid–liquid phase separation (LLPS) is a novel mechanism to explain the formation of membraneless organelles and their functions in biology. The physiological role and pathological function of LLPS are emerging topics for basic research. This course aims to introduce the concept of LLPS, approaches to study LLPS and the role of LLPS in cells. Additionally, the li<x>nks of LLPS and diseases such as neurodegenerative disorders, cancers and SARS-CoV-2 will be discussed.
Course keywords: 液相分離, 蛋白質, 胞器, 病程進展, Liquid-liquid phase separation, protein, organelle, pathogenesis. Text Books: N/A References: Methods in Enzymology Volume 646 (January 2021) Teaching Method: English lecture combined with latest journal paper discussion. Syllabus: Week 1: Introduction Week 2: Basic Concepts of liquid–liquid phase separation Week 3: Method to study LLPS Week 4: Sequence-specific coarse-grained model Week 5: Cell-free reconstitution of multi-condensate assemblies Week 6: Characterizing the material properties of biomolecular condensates Week 7: Measuring the activity and structure condensates inside liquid-liquid phase separation Week 8: Panel discussion Week 9: Mid-term Week 10: LLPS and diseases Week 11: Alzheimer/Parkinson diseases and LLPS Week 12: Frontotemporal dementia and LLPS Week 13: Amyotrophic lateral sclerosis and LLPS Week 14: Cancer and LLPS Week 15: SARS-CoV-2 and LLPS Week 16: LLPS, organelles and pathogenesis Week 17: Panel discussion Week 18: Final Exam Evaluation: 40 % - Mid-term Exam 40 % - Final Exam 15 % - Discussion in the classes 5 % - Attendance AI is conditionally open for use in this course. Students have to specify how generative AI will be used in course output. Website: E-learning platform: eeclass of National Tsing Hua University
MON | TUE | WED | THU | FRI | |
08:00108:50 | |||||
09:00209:50 | |||||
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19:30b20:20 | |||||
20:30c21:20 |
Average GPA 4.15
Std. Deviation 0.15
16週, 需與授課教師討論後加簽選課Requiring application in order to enroll in the course.
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